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Inhalation Toxicity of Talc

  • Market Insight 30 September 2020 30 September 2020
  • Americas

  • Insurance & Reinsurance

The debate over the correlation between talc-induced lung diseases and contamination from asbestos fibers continues on, given the lack of sufficient exposure data. The unique mineral elements of talc, along with accessory minerals, create respirable talc powder (RTP). Diseases relating to fibrotic and neoplastic have been found in workers within the talc-ore processing industries, along with those who use talc for cosmetic uses. Case studies from 1940 to 1990 observed the results of occupational hygiene and animal inhalation, which were done both in vivo and in vitro. Analysis of talc toxicity studies that observed occupational uses did not confirm any concrete evidence of the correlation between aerosol components and pulmonary cancer. The studies have found a link between the aerosols and pleural and pulmonary fibrosis, and the development of nonmalignant respiratory disease. The results of the in vivo and in vitro studies appeared to mirror the experimental results for animal inhalation and implantation studies.

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